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Product Infomation
Product Name Dual-Chamber Membrane-Based Microfluidic Chip
Catalog Number OOC-051
Description The dual-chamber membrane-based chip features independent upper and lower flow channels separated by a biocompatible porous membrane. Different cell types can be cultured on either side of the membrane and interact through the porous membrane, creating a tissue-barrier interface structure similar to that found in the human body. Simultaneously, the chip integrates fluid flow and immune cells to reproduce the complex biological microenvironment found in vivo; notably, the dual-chamber membrane-based chip enables the construction of two serialized tissue organs on a single chip.
Applications Two cascaded or modularly connected multi-organ cascade models, such as alveolar-bronchial, brain-gut axis, and liver-gut models; Disease model construction, such as IPF and DM models; drug screening and toxicity assessment; cosmetic safety and efficacy evaluation; basic scientific research, such as mechanisms of inflammation, drug resistance, and viral infection.
Features Enables the stable construction of classic multi-layer and barrier-function organ-on-a-chip models. Can serve as independent units to achieve cascaded interactions among multi-level barrier organoid units. The upper and lower chambers are independently controlled, enabling continuous unidirectional perfusion culture via gas-liquid or liquid-liquid methods; combined with a fluid control system, flow rates can be precisely regulated. A single chip can construct two series-connected tissue-organ units (dual-chamber membrane chips) to study the interactions between two tissues or organs. The addition of a bubble collection unit eliminates damage to cells caused by bubbles during culture. The upper and lower chambers are separated by a porous membrane, ensuring the independence of cells and tissues while simulating the hierarchical structure of cells at tissue interfaces within human organs. This design facilitates the exchange of substances and signals.
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