Tanspiramycin (17-AAG)lipid nanoparticle

We can offer a discount on bulk orders. Please contact our sales team for further inquiry.

Product Infomation

Product Name	Tanspiramycin (17-AAG)lipid nanoparticle
Catalog Number	LNP-010
Size	10 mg; 20 mg; 50 mg
Alias	Tanespimycin (17-AAG)LNP; Geldanamycin derivative lipid nanoparticle delivery system
Appearance	Light yellow to amber homogeneous suspension
Solubility	It can be dispersed in physiological buffer or 5% glucose solution to form a stable colloidal dispersion system
Description	Tanespimycin (17-AAG)LNP is a specialized nano-lipid nanoparticle formulation of the heat shock protein 90 inhibitor tanspiromycin (tanespimycin, 17-AAG). 17-AAG, as a water-soluble derivative of geldanamycin, specifically binds to the ATP-binding pocket of HSP90 and induces the ubiquitination and degradation of its proteins (such as various kinases and transcription factors), thereby interfering with the proliferation, survival and metastasis signaling pathways of tumor cells. Although its water solubility is improved compared with the parent compound, it still faces challenges such as insufficient solubility, rapid metabolism in the body, and lack of tumor targeting.
Applications	Development of nano-delivery system for poorly soluble HSP90 inhibitors
Storage	4°C, protected from light
Purity	95%+
Shelf Life	1 Year
Shipping Condition	Low temperature transport

Online Inquiry