Tanespimycin (17-AAG) LNP,tanspiramycin (17-AAG) liposome

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Product Infomation

Product Name	Tanespimycin (17-AAG) LNP,tanspiramycin (17-AAG) liposome
Catalog Number	R-ZZTBSSDL-109
Alias	Geldanamycin derivative liposome delivery system
Appearance	Light yellow to amber homogeneous suspension
Molecular Formula	N/A
Solubility	Can be reconstituted in physiological buffer or 5% glucose solution to form a stable colloidal dispersion system
Storage	4°C, protected from light
Purity	95%+
Shelf Life	1 year
Shipping Condition	low temperature transport
Application	Development of nano-delivery system for poorly soluble HSP90 inhibitors
Specification	10mg：Inquiry 20mg：Inquiry 50mg：Inquiry
Description	Tanespimycin (17-AAG) LNP is a specialized nanoliposome formulation of the heat shock protein 90 inhibitor tanspiromycin (Tanespimycin, 17-AAG). 17-AAG, as a water-soluble derivative of geldanamycin, specifically binds to the ATP-binding pocket of HSP90 and induces the ubiquitination and degradation of its proteins (such as various kinases and transcription factors), thereby interfering with the proliferation, survival and metastasis signaling pathways of tumor cells. Although its water solubility is improved compared with the parent compound, it still faces challenges such as insufficient solubility, rapid metabolism in the body, and lack of tumor targeting.

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