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Product Infomation
Product Name Recombinant Rat Platelet-Derived Growth Factor BB
Catalog Number PGF-008
Size 2µg;10µg;1mg
Description PDGF-BB is a member of the platelet-derived growth factor family. All four members of this family are mitogenic factors for mesenchymal-derived cells, characterized by the presence of eight cysteine residues. The gene product can exist as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha peptide (PDGF-AB), in which the heterodimer is linked by disulfide bonds. Mutations in this gene are associated with meningiomas. On chromosomes 22 and 7, reciprocal translocations involving this gene and the COL1A1 gene locus are associated with a specific type of skin tumor called dermatofibrosarcoma protuberans, which is caused by dysregulation of growth factor expression. Two splicing variants of this gene have been identified to date.
Application This product can be used for research on facilitating rat-specific vascular studies with rat PDGF-BB.
Molecular Weight 24.4 kDa
Species Rat
Source E.coli
Appearance Sterile-filtered white lyophilized powder
Purity ≥ 98% by SDS-PAGE, RP-HPLC
Activity The ED₅₀ was determined using a cell proliferation assay with mouse Balb/c 3T3 cells, with a concentration below 2.0 ng/mL, equivalent to an activity of >5.0 × 10⁵ IU/mg.
Redissolution It is recommended to reconstitute lyophilized PDGF-BB with sterile 18 mM H₂O to a concentration of at least 100 µg/mL, after which it may be further diluted into other aqueous solutions.
Formulation PDGF-BB was lyophilized from a concentrated solution of 1x PBS (pH 7.0) filtered through a 0.2 µm filter.
Amino Acid Sequence SLGSLAAAEP AVIAECKTRT EVFQISRNLI DRTNANFLVW PPCVEVQRCS GCCNNRNVQC RASQVQMRPV QVRKIEIVRK KPVFKKATVT LEDHLACKCE TVVTPRPVT
Storage Store at room temperature for 3 weeks, or in a dry environment at -18°C or below. After reconstitution, store at 4°C for 2-7 days; thereafter, store at -18°C or below for future use. Avoid repeated freeze-thaw cycles.
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