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Product Infomation
Product Name Recombinant Mouse Platelet-Derived Growth Factor BB
Catalog Number PGF-007
Size 2µg;10µg;1mg
Description PDGF-BB is a member of the platelet-derived growth factor family. All four members of this family are mitogenic factors for mesenchymal-derived cells, characterized by the presence of eight cysteine residues. The gene product can exist as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha peptide (PDGF-AB), in which the heterodimer is linked by disulfide bonds. Mutations in this gene are associated with meningiomas. On chromosomes 22 and 7, reciprocal translocations involving this gene and the COL1A1 gene locus are associated with a specific type of skin tumor called dermatofibrosarcoma protuberans, which is caused by dysregulation of growth factor expression. Two splicing variants of this gene have been identified to date.
Application This product can be used for research on supporting murine vascular tissue engineering with mouse PDGF-BB.
Molecular Weight 24.7 kDa
Species Mouse
Source E.coli
Appearance Sterile-filtered white lyophilized powder
Purity ≥ 95% by SDS-PAGE, RP-HPLC
Activity Biological activity was determined by the dose-dependent stimulation of human umbilical vein endothelial cells (HUVEC) proliferation at concentrations below 1.6 ng/mL.
Redissolution It is recommended to reconstitute lyophilized platelet-derived growth factor-BB in sterile 100 mM acetic acid and 0.1% BSA solution to a concentration of at least 100 µg/mL, after which it may be further diluted into other aqueous solutions.
Formulation This protein was lyophilized from a 10 mM sodium citrate solution (pH 3.0).
Amino Acid Sequence MSLGSLAAAE PAVIAECKTR TEVFQISRNL IDRTNANFLV WPPCVEVQRC SGCCNNRNVQ CRASQVQMRP VQVRKIEIVR KKPIFKKATV TLEDHLACKC ETIVTPRPVT
Storage Store at room temperature for 3 weeks, or in a dry environment at -18°C or below. After reconstitution, store at 4°C for 2-7 days; thereafter, store at -18°C or below for future use. Avoid repeated freeze-thaw cycles.
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