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Product Infomation
Product Name Recombinant Human Vascular Endothelial Growth Factor C
Catalog Number VGF-005
Size 2µg;10µg;1mg
Description Vascular Endothelial Growth Factor-C (VEGF-C), also known as Vascular Endothelial Growth Factor-Related Protein (VRP), is a recently discovered member of the VEGF family of growth factors and is most closely related to VEGF-D. Human VEGF-C cDNA encodes a precursor protein consisting of 416 amino acid residues, whose structure is almost identical to that of the mouse VEGF-C protein. Similar to VEGF-D, VEGF-C possesses a VEGF-homologous domain located in the middle third of the precursor molecule, as well as longer N-terminal and C-terminal extension sequences. In adults, VEGF-C is highly expressed in the heart, placenta, ovaries, and small intestine. The recombinant human VEGF-C protein lacks the N-terminal and C-terminal extension sequences and contains only the central VEGF-homologous domain; it primarily exists as a non-covalently linked dimer. This protein is a ligand for VEGFR-2/KDR and VEGFR-3/FLT-4. Since VEGFR-3 is highly expressed in lymphatic endothelial cells, it is hypothesized that VEGF-C participates in the regulation of lymphatic endothelial cell growth and/or differentiation. Although recombinant human VEGF-C also acts as a mitogen for vascular endothelial cells, its potency is significantly lower than that of VEGF-A.
Application This product can be used for research on promoting lymphatic endothelial cell proliferation in tissue engineering with human VEGF-C.
Molecular Weight 18-24 kDa
Species Human
Source Sf9, Insect cells
Appearance Sterile-filtered white lyophilized powder
Purity ≥ 90% by SDS-PAGE
Activity Assessed by its ability to induce VEGFR-3/FLT-4 receptor phosphorylation in PAEC/VEGFR3 cells and to stimulate the proliferation of primary HDLEC cells via VEGFC.
Redissolution It is recommended to reconstitute lyophilized VEGF-C with sterile 18 MΩ-cm H₂O to a concentration of at least 100 µg/mL, after which it may be further diluted into other aqueous solutions.
Formulation Each milligram of the human VEGF-C preparation contains 50 mg of BSA and 1× PBS as a buffer.
Storage Store at room temperature for 3 weeks, or in a dry environment at -18°C or below. After reconstitution, store at 4°C for 2-7 days; thereafter, store at -18°C or below for future use. Avoid repeated freeze-thaw cycles.
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