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We can offer a discount on bulk orders. Please contact our sales team for further inquiry.| Product Name | Recombinant Human Transforming Growth Factor Beta 1 |
| Catalog Number | TGF-003 |
| Size | 2µg;10µg;100µg |
| Description | Transforming growth factor beta (TGFBeta) mediates many intercellular interactions that occur during embryonic development. Three TGFBeta isoforms have been identified in mammals: TGFBeta1, TGFBeta2, and TGFBeta3. All three TGFBetas are synthesized as very similar precursor proteins; they are all cleaved to produce a 112-amino acid peptide that remains bound to the latent portion of the molecule. |
| Application | This product can be used for research on regulating extracellular matrix synthesis and cell differentiation with human TGF-β1. |
| Molecular Weight | 25.6 kDa |
| Species | Human |
| Source | CHO cells |
| Appearance | Sterile-filtered white lyophilized powder |
| Purity | ≥ 95% by SDS-PAGE |
| Activity | The ED₅₀ was determined by dose-dependent inhibition of IL-4-induced HT-2 cell proliferation and was found to be 0.142 ng/mL, corresponding to an activity of 7.4 × 10⁶ units/mg. |
| Redissolution | It is recommended to resuspend the lyophilized TGFB1 in sterile 10 mM HCl to a concentration of 0.1 mg/mL, after which it may be further diluted into other aqueous solutions. |
| Formulation | It was lyophilized from a sterile-filtered solution containing 0.1% trifluoroacetic acid (TFA) and trehalose (protein to trehalose ratio of 1:20). |
| Amino Acid Sequence | ALDTNYCFSS TEKNCCVRQL YIDFRKDLGW KWIHEPKGYH ANFCLGPCPY IWSLDTQYSK VLALYNQHNP GASAAPCCVP QALEPLPIVY YVGRKPKVEQ LSNMIVRSCK CS |
| Storage | Store at room temperature for 3 weeks, or in a dry environment at -18°C or below. After reconstitution, store at 4°C for 2-7 days; thereafter, store at -18°C or below for future use. Avoid repeated freeze-thaw cycles. |