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Product Infomation
Product Name Recombinant Human Platelet Derived Growth Factor D
Catalog Number PGF-010
Size 5µg;20µg;1mg
Description Platelet-derived growth factor D (PDGFD) belongs to the platelet-derived growth factor family. The product of the PDGFD gene forms only homodimers and therefore does not form dimers with the other three family members. PDGFD plays a crucial role in wound healing. During angiogenesis, PDGFD induces macrophage recruitment, increases interstitial pressure, and promotes vascular maturation. PDGFD initiates a series of events that ultimately lead to mesangial proliferative glomerulonephritis, including the infiltration of monocytes and macrophages and the production of extracellular matrix. All four members of the PDGF family are mitogenic factors for mesenchymal-derived cells; they all possess a core motif consisting of eight cysteines, seven of which are present in PDGFD. PDGFD differs from the α and β members of this family in that it possesses a unique N-terminal domain, the CUB domain.
Application This product can be used for research on modulating fibroblast and smooth muscle cell activity with human PDGF-D.
Molecular Weight 16.6 kDa
Species Human
Source E.coli
Appearance Sterile-filtered colorless solution
Purity ≥ 90% by SDS-PAGE
Formulation The PDGFD solution (1 mg/mL) contains 20 mM Tris-HCl buffer (pH 8.0), 0.4 M urea, and 10% glycerol.
Amino Acid Sequence MGSSHHHHHH SSGLVPRGSH MGSHM SYHDR KSKVDLDRLN DDAKRYSCTP RNYSVNIREE LKLANVVFFP RCLLVQRCGG NCGCGTVNWR SCTCNSGKTV KKYHEVLQFE PGHIKRRGRA KTMALVDIQL DHHERCDCIC SSRPPR
Storage Store at 4°C for 2-4 weeks. For long-term storage, freeze at -20°C. For long-term storage, we recommend adding a carrier protein (0.1% HSA or BSA). Avoid repeated freeze-thaw cycles.
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For Research or Industrial Raw Materials, Not For Personal Medical Use!
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