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Product Infomation
Product Name Recombinant Human Platelet Derived Growth Factor CC
Catalog Number PGF-006
Size 5µg;20µg;1mg
Description Platelet-derived growth factor-CC (PDGF-CC) belongs to the PDGF family of growth factors. PDGF-CC binds with high affinity to PDGF Ra and activates the PDGF R-ab heterodimer. During development, PDGF-CC is involved in ductal morphogenesis and the proliferation of cardiovascular smooth muscle cells; furthermore, PDGF-CC is also an angiogenic factor. PDGF-CC is expressed in various tumors and tumor cell lines and may be associated with tumorigenesis.
Application This product can be used for research on regulating connective tissue cell proliferation in tissue engineering with human PDGF-CC.
Molecular Weight 26.8 kDa
Species Human
Source E.coli
Appearance Sterile-filtered white lyophilized powder
Purity ≥ 97% by SDS-PAGE
Activity The ED₅₀ determined using proliferation assays with mouse NR6R-3T3 cells was less than 350 ng/mL.
Redissolution It is recommended to reconstitute lyophilized PDGF-CC with sterile 18 MΩ-cm H₂O to a concentration of at least 100 µg/mL, after which it may be further diluted into other aqueous solutions.
Formulation Lyophilized from a solution of acetonitrile and trifluoroacetic acid after filtration through a 0.2 µm filter.
Amino Acid Sequence MHHHHHHVVD LNLLTEEVRL YSCTPRNFSV SIREELKRTD TIFWPGCLLV KRCGGNCACC LHNCNECQCV PSKVTKKYHE VLQLRPKTGV RGLHKSLTDV ALEHHEECDC VCRGSTGG
Storage Store at room temperature for 3 weeks, or in a dry environment at -18°C or below. After reconstitution, store at 4°C for 2-7 days; thereafter, store at -18°C or below for future use. Avoid repeated freeze-thaw cycles.
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