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Product Infomation
Product Name Recombinant Human Platelet-Derived Growth Factor BB
Catalog Number PGF-005
Size 2µg;10µg;1mg
Description PDGF-BB is a member of the platelet-derived growth factor family. All four members of this family are mitogenic factors for mesenchymal-derived cells, characterized by the presence of eight cysteine residues. The gene product can exist as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha peptide (PDGF-AB), in which the heterodimer is linked by disulfide bonds. Mutations in this gene are associated with meningiomas. On chromosomes 22 and 7, reciprocal translocations involving this gene and the COL1A1 gene locus are associated with a specific type of skin tumor called dermatofibrosarcoma protuberans, which is caused by dysregulation of growth factor expression. Two splicing variants of this gene have been identified to date.
Application This product can be used for research on enhancing wound healing and angiogenesis with human PDGF-BB homodimer.
Molecular Weight 24.3 kDa
Species Human
Source E.coli
Appearance Sterile-filtered white lyophilized powder
Purity ≥ 95% by SDS-PAGE, RP-HPLC
Activity Determined by dose-dependent stimulation of Balb/c 3T3 cell proliferation. The estimated ED₅₀ for this effect was 1.0-3.0 ng/mL.
Redissolution It is recommended to reconstitute lyophilized platelet-derived growth factor-BB with sterile 18 MΩ-cm H₂O to a concentration of at least 100 µg/mL, after which it may be further diluted into other aqueous solutions.
Formulation A concentrated PBS solution (pH 7.4) was filtered through a 0.2 µm filter and then lyophilized.
Amino Acid Sequence SLGSLTIAEP AMIAECKTRT EVFEISRRLI DRTNANFLVW PPCVEVQRCS GCCNNRNVQC RPTQVQLRPV QVRKIEIVRK KPIFKKATVT LEDHLACKCE TVAAARPVT
Storage Store at room temperature for 3 weeks, or in a dry environment at -18°C or below. After reconstitution, store at 4°C for 2-7 days; thereafter, store at -18°C or below for future use. Avoid repeated freeze-thaw cycles.
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