We can offer a discount on bulk orders. Please contact our sales team for further inquiry.
Product Infomation
Product Name Recombinant Human Platelet-Derived Growth Factor AB
Catalog Number PGF-003
Size 2µg;10µg;1mg
Description The term “PDGF” refers to a class of disulfide-linked dimeric isoforms that function as autocrine and paracrine growth factors and are produced by various cell types other than platelets. They exert potent mitogenic effects on nearly all mesenchymal-derived cells. Abnormal expression is associated with certain cancers, fibroproliferative diseases, and atherosclerosis. The protein also contributes to wound healing and nerve regeneration. The PDGF family comprises four members: PDGF-A, PDGF-B, PDGF-C, and PDGF-D. PDGF-A exists in two distinct forms: a soluble short-chain form and a long-chain form that remains anchored in the extracellular matrix.
Application This product can be used for research on modulating heterodimeric PDGF signaling in tissue engineering with human PDGF-AB.
Molecular Weight 26.4 kDa
Species Human
Source E.coli
Appearance Sterile-filtered white lyophilized powder
Purity ≥ 95% by SDS-PAGE
Activity Determined by a dose-dependent proliferation assay using mouse 3T3 indicator cells, the ED₅₀ was 1.4-2.1 ng/mL. This corresponds to a specific activity of 7.1 × 10⁵ units/mg.
Redissolution It is recommended to reconstitute lyophilized platelet-derived growth factor-AB with sterile 18 MΩ-cm H₂O to a concentration of no less than 100 µg/mL, after which it may be further diluted into other aqueous solutions.
Formulation Lyophilized from a 10 mM acetic acid (AcOH) solution.
Amino Acid Sequence Alpha chain: MSIEEAVPAV CKTRTVIYEI PRSQVDPTSA NFLIWPPCVE VKRCTGCCNT SSVKCQPSRV HHRSVKVAKV EYVRKKPKLK EVQVRLEEHL ECACATTSLN PDYREEDTGR PRESGKKRKR KRLKPT
Beta chain: SLGSLTIAEP AMIAECKTRT EVFEISRRLI DRTNANFLVW PPCVEVQRCS GCCNNRNVQC RPTQVQLRPV QVRKIGIVRK KPIFKKATVT LGDHLACKCE TVAAARPVT
Storage Store at room temperature for 3 weeks, or in a dry environment at -18°C or below. After reconstitution, store at 4°C for 2-7 days; thereafter, store at -18°C or below for future use. Avoid repeated freeze-thaw cycles.
Online Inquiry
For Research or Industrial Raw Materials, Not For Personal Medical Use!
Place the Order
FAQs
logo

Enter your email here to subscribe.

Copyright © MATEXCEL. All Rights Reserved.
0
Inquiry Basket