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Product Infomation
Product Name Recombinant Human Connective Tissue Growth Factor
Catalog Number CGF-001
Size 5µg;20µg;1mg
Description Connective Tissue Growth Factor belongs to the CCN protein family. The CCN family currently comprises six members in humans, also known as: Cyr61 (Cysteine-rich 61), CTGF (Connective Tissue Growth Factor), Nov (Nephroblastoma Overexpression Gene), and WISP-1, 2, and 3 (Wnt-1-induced secreted proteins). CCN genes encode secreted proteins associated with the extracellular matrix (ECM) and cell membranes. CCN proteins are extracellular matrix proteins involved in the regulation of various cellular functions, including proliferation, differentiation, survival, adhesion, and migration. They are expressed in derivatives of the embryonic three germ layers and participate in the development of the kidneys, nervous system, muscles, bone marrow, cartilage, and skeleton. In adulthood, they are involved in wound healing, fracture repair, and pathological processes such as fibrosis, vascular diseases, and tumorigenesis.
Application This product can be used for research on regulating fibroblast proliferation and extracellular matrix production in connective tissue engineering with human CTGF.
Molecular Weight 11.2 kDa
Species Human
Source E.coli
Appearance Sterile-filtered white lyophilized powder
Purity ≥ 90% by SDS-PAGE
Activity Activity was determined by dose-dependent stimulation of HUVEC cell proliferation. The expected ED₅₀ for this effect is 1-2 µg/mL, corresponding to a specific activity of 500-1,000 units/mg.
Redissolution It is recommended to reconstitute lyophilized CTGF with sterile 18 MΩ·cm H₂O to a concentration of at least 100 µg/mL, after which it may be further diluted into other aqueous solutions.
Formulation CTGF was lyophilized from a solution of sterile filtered water containing 0.1% trifluoroacetic acid (TFA).
Amino Acid Sequence MGKKCIRTPK ISKPIKFELS GCTSMKTYRA KFCGVCTDGR CCTPHRTTTL PVEFKCPDGE VMKKNMMFIK TCACHYNCPG DNDIFESLYY RKMYGDMA
Storage Store at room temperature for 3 weeks, or in a dry environment at -18°C or below. After reconstitution, store at 4°C for 2-7 days; thereafter, store at -18°C or below for future use. Avoid repeated freeze-thaw cycles.
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