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Product Infomation
Product Name Recombinant Equine Platelet-Derived Growth Factor BB
Catalog Number PGF-009
Size 10µg;50µg;100µg
Description PDGF-BB is a member of the platelet-derived growth factor family. All four members of this family are mitogenic factors for mesenchymal-derived cells, characterized by the presence of eight cysteine residues. The gene product can exist as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha peptide (PDGF-AB), in which the heterodimer is linked by disulfide bonds. Mutations in this gene are associated with meningiomas. On chromosomes 22 and 7, reciprocal translocations involving this gene and the COL1A1 gene locus are associated with a specific type of skin tumor called dermatofibrosarcoma protuberans, which is caused by dysregulation of growth factor expression. Two splicing variants of this gene have been identified to date.
Application This product can be used for research on promoting equine tissue regeneration in veterinary tissue engineering with equine PDGF-BB.
Molecular Weight 24.8 kDa
Species Equine
Source E.coli
Appearance Sterile-filtered white lyophilized powder
Purity ≥ 95% by SDS-PAGE
Activity The ED₅₀ determined by the 3T3 proliferation assay was ≤ 30 ng/mL, corresponding to a specific activity of ≥ 3.3 × 10⁴ units/mg.
Redissolution It is recommended to reconstitute lyophilized PDGF-BB with sterile water to a concentration of 0.1 mg/mL, after which it may be further diluted into other aqueous solutions.
Formulation Lyophilized from a solution containing 10 mM sodium phosphate, pH 7.5, which was sterile-filtered (0.2 µm).
Amino Acid Sequence MSLGSLAVAE PAMIAECKTR TEVFEISRRL IDRTNANFLV WPPCVEVQRC SGCCNNRHVQ CRPTQVQLRP VQVRKIEIVR KKPTFKKATV TLEDHLACKC ETVGAARPVT 
Storage Store at room temperature for 3 weeks, or in a dry environment at -18°C or below. After reconstitution, store at 4°C for 2-7 days; thereafter, store at -18°C or below for future use. Avoid repeated freeze-thaw cycles.
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