PH-responsive lipid nanoparticles

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Product Infomation

Product Name	PH-responsive lipid nanoparticles
Catalog Number	LNP-155
Size	50 mg; 100 mg; 500 mg
Alias	PH-LNP; PH lipid nanoparticle
Appearance	Dispersion/lyophilized powder/freeze-thawable dispersion
Solubility	Pure water dispersion
Description	The main components of pH-responsive lipid nanoparticles are: DOPE and CHEMS (carboxylated cholesterol), which can achieve sensitive detection of specific biomolecules or environments by introducing appropriate biosensing molecules. As a pH-sensitive lipid, DOPE's phosphoethanolamine head group is protonated under acidic conditions (pH<6.5), Inducing the lipid membrane to transform from the lamellar phase (Lα)to the hexagonal phase (HII), forming a non-bilayer structure to promote drug release. The CHEMS carboxyl group is negatively charged at physiological pH (7.4), And forms an ion pair with the positively charged head of DOPE to stabilize the membrane structure; When the pH drops to the endosomal level (5.0-6.5), The protonation of the carboxyl group weakens the electrostatic interaction and accelerates the disintegration of the membrane structure.
Applications	Delivery vehicle
Storage	-20°C, protected from light
Purity	95%+
Shelf Life	1 Month (dispersion)/3-6 months (lyophilized powder)/6-12 months (freeze-thawable dispersion)
Shipping Condition	Low temperature transport

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