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Product Infomation
Product Name pH-LNP, pH-responsive liposomes
Catalog Number R-PHLNP
Alias pH Liposome
Appearance Dispersion/lyophilized powder/freeze-thawable dispersion
Molecular Formula N/A
Solubility Pure water dispersion
Storage -20°C, protected from light
Purity 95%+
Shelf Life 1 month (dispersion)/3-6 months (lyophilized powder)/6-12 months (freeze-thawable dispersion)
Shipping Condition low temperature transport
Application delivery vehicle
Specification 50mg：Inquiry
100mg：Inquiry
500mg：Inquiry
Description The main components of pH-responsive liposomes are: DOPE and CHEMS (carboxylated cholesterol), which can achieve sensitive detection of specific biomolecules or environments by introducing appropriate biosensing molecules. As a pH-sensitive lipid, DOPE's phosphoethanolamine head group is protonated under acidic conditions (pH<6.5), inducing the lipid membrane to transform from the lamellar phase (Lα) to the hexagonal phase (HII), forming a non-bilayer structure to promote drug release. The CHEMS carboxyl group is negatively charged at physiological pH (7.4), and forms an ion pair with the positively charged head of DOPE to stabilize the membrane structure; when the pH drops to the endosomal level (5.0-6.5), the protonation of the carboxyl group weakens the electrostatic interaction and accelerates the disintegration of the membrane structure. pH-responsive liposomes are functional liposomes with intracellular targeting and controlled release of drugs (such as genes, nucleic acids, peptides, proteins). Its key property lies in its pH responsiveness, that is, under specific pH conditions, liposomes can undergo structural changes to release the encapsulated drugs. This property mainly relies on the specific chemical bonds contained in the liposomes, such as acylhydrazone bonds and diselenium bonds. Customized services such as DSPE-PEG doping, DSPE-PEG-polypeptide/aptamer, DSPE-PEG-dye doping, cationic phospholipid (such as DOTAP) doping, cell membrane hybridization, and nanoparticle compounding are available to meet a variety of requirements.
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For Research or Industrial Raw Materials, Not For Personal Medical Use!
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