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Product Infomation
Product Name Mirdametinib (PD0325901)lipid nanoparticle
Catalog Number LNP-008
Size 10 mg; 20 mg; 50 mg
Alias Mirdametinib (PD0325901)LNP; PD0325901 long circulation targeted lipid nanoparticles
Appearance Off-white to light yellow homogeneous suspension
Solubility It can be dispersed in physiological buffer or 5% glucose solution to form a stable colloidal dispersion system
Description Mirdametinib (PD0325901)LNP is a specialized nano-lipid nanoparticle formulation of the selective MEK1/2 inhibitor mirdametinib (PD0325901). PD0325901 inhibits abnormal activation of the MAPK signaling pathway by highly selectively inhibiting MEK1/2 kinase activity and blocking downstream ERK phosphorylation, showing anti-proliferative activity in a variety of RAS/RAF mutant tumors. However, its limited water solubility, low oral bioavailability, rapid metabolism, and dose-limiting tox limit its research application potential.
Applications Optimization of nanodelivery systems for MAPK pathway inhibitors
Storage 4°C, protected from light
Purity 95%+
Shelf Life 1 Year
Shipping Condition Low temperature transport
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