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Product Infomation
Product Name Mirdametinib (PD0325901) LNP, Mirdametinib (PD0325901) liposome
Catalog Number R-ZZTBSSDL-111
Alias PD0325901 long circulation targeted liposomes
Appearance Off-white to light yellow homogeneous suspension
Molecular Formula N/A
Solubility Can be reconstituted in physiological buffer or 5% glucose solution to form a stable colloidal dispersion system
Storage 4°C, protected from light
Purity 95%+
Shelf Life 1 year
Shipping Condition low temperature transport
Application Optimization of nanodelivery systems for MAPK pathway inhibitors
Specification 10mg:Inquiry
20mg:Inquiry
50mg:Inquiry
Description Mirdametinib (PD0325901) LNP is a specialized nanoliposome formulation of the selective MEK1/2 inhibitor Mirdametinib (PD0325901). PD0325901 inhibits abnormal activation of the MAPK signaling pathway by highly selectively inhibiting MEK1/2 kinase activity and blocking downstream ERK phosphorylation, showing anti-proliferative activity in a variety of RAS/RAF mutant tumors. However, its limited water solubility, low oral bioavailability, rapid metabolism, and dose-limiting Tox limit its clinical application potential.
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