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| Product Name | Mirdametinib (PD0325901) LNP, Mirdametinib (PD0325901) liposome |
| Catalog Number | R-ZZTBSSDL-111 |
| Alias | PD0325901 long circulation targeted liposomes |
| Appearance | Off-white to light yellow homogeneous suspension |
| Molecular Formula | N/A |
| Solubility | Can be reconstituted in physiological buffer or 5% glucose solution to form a stable colloidal dispersion system |
| Storage | 4°C, protected from light |
| Purity | 95%+ |
| Shelf Life | 1 year |
| Shipping Condition | low temperature transport |
| Application | Optimization of nanodelivery systems for MAPK pathway inhibitors |
| Specification | 10mg:Inquiry 20mg:Inquiry 50mg:Inquiry |
| Description | Mirdametinib (PD0325901) LNP is a specialized nanoliposome formulation of the selective MEK1/2 inhibitor Mirdametinib (PD0325901). PD0325901 inhibits abnormal activation of the MAPK signaling pathway by highly selectively inhibiting MEK1/2 kinase activity and blocking downstream ERK phosphorylation, showing anti-proliferative activity in a variety of RAS/RAF mutant tumors. However, its limited water solubility, low oral bioavailability, rapid metabolism, and dose-limiting Tox limit its clinical application potential. |