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Product Infomation
Product Name LNP@GFP, lipid nanoparticles encapsulating green fluorescent protein
Catalog Number R-CW-RZ100
Alias Liposome-encapsulated GFP protein
Appearance Dispersion
Molecular Formula N/A
Solubility Dispersed in water or PBS buffer
Storage 2-8°C, protected from light
Purity 95%+
Shelf Life 1 year
Shipping Condition low temperature transport
Application Preparation of liposomes
Specification 5ml: Inquiry
10ml: Inquiry
20ml: Inquiry
Description LNP@GFP protein is a biological nanocomplex that encapsulates green fluorescent protein inside lipid nanoparticles (LNP). Lipid nanoparticles are mainly composed of ionizable cationic phospholipids, cholesterol, auxiliary phospholipids and polyethylene glycol modified phospholipids. Under physiological pH conditions, ionizable cationic phospholipids are neutral and are protonated and positively charged in acidic environments such as endosomes. They can tightly bind to negatively charged or polar GFP proteins through electrostatic interactions to achieve efficient encapsulation. Cholesterol enhances membrane fusion, which helps the LNP@GFP protein to be taken up by cells and promote the escape of GFP protein from endosomes into the cytoplasm. Auxiliary phospholipids stabilize the phospholipid bilayer structure and maintain the stability of LNP morphology. Polyethylene glycol-modified phospholipids are located on the surface of LNP to prevent particle aggregation, prolong their circulation time in the body, and avoid rapid clearance by the immune system. Green fluorescent protein is a protein from Aequorea victoria that spontaneously produces green fluorescence when excited by blue or ultraviolet light without adding a substrate. After combining with LNP, it not only improves the stability and cellular uptake efficiency of GFP protein, but also visually tracks the delivery and expression process of the protein through fluorescence signals, providing a powerful tool for biomedical research and applications.
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