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Product Infomation
Product Name LNP@Fe3O4-TPP-FITC, lipid nanoparticles wrapped with iron ferric oxide-triphenylphosphine-fluorescein isothiocyanate
Catalog Number R-CW-F020
Alias Liposome-coated ferric oxide surface modification TPP and FITC
Appearance Dispersion
Molecular Formula N/A
Solubility Dispersed in water or PBS buffer
Storage 2-8°C, protected from light
Purity 95%+
Shelf Life 1 year
Shipping Condition low temperature transport
Application Preparation of liposomes
Specification 10mg：Inquiry
20mg：Inquiry
50mg：Inquiry
Description LNP@Fe3O4-TPP-FITC is a constructed multifunctional nanocomposite that co-encapsulates ferric oxide nanoparticles, triphenylphosphine and fluorescein isothiocyanate inside lipid nanoparticles (LNP). Lipid nanoparticles are mainly composed of ionizable cationic phospholipids, cholesterol, auxiliary phospholipids and polyethylene glycol modified phospholipids. Under physiological pH conditions, ionizable cationic phospholipids are neutral, protonated and positively charged in acidic environments such as endosomes, and can be tightly combined with negatively charged or polar Fe3O4, TPP, and FITC through electrostatic interactions, hydrophobic interactions, etc. to achieve efficient encapsulation. Cholesterol enhances membrane fusibility and helps LNP@Fe3O4-TPP-FITC to be taken up by cells and promote the escape of Fe3O4, TPP and FITC from endosomes into the cytoplasm. Auxiliary phospholipids stabilize the phospholipid bilayer structure and maintain the stability of LNP morphology. Polyethylene glycol-modified phospholipids are located on the surface of LNP to prevent particle aggregation, prolong their circulation time in the body, and avoid rapid clearance by the immune system. Ferric oxide is superparamagnetic and can achieve directional movement and enrichment under the influence of an external magnetic field; triphenylphosphine has certain biological targeting and can guide the complex to aggregate to specific cells or tissues; fluorescein isothiocyanate is a commonly used fluorescent dye that can produce a strong green fluorescence signal when excited by light of a specific wavelength.
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