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Product Infomation
Product Name LNP@EGFp-mRNA, lipid nanoparticles encapsulating enhanced green fluorescent protein messenger ribonucleic acid
Catalog Number R-CW-ER001
Alias Liposome-encapsulated EGFp-mRNA
Appearance Dispersion
Molecular Formula N/A
Solubility Dispersed in water or PBS buffer
Storage 2-8°C, protected from light
Purity 95%+
Shelf Life 1 year
Shipping Condition low temperature transport
Application Preparation of liposomes
Specification 10mg：Inquiry
20mg：Inquiry
50mg：Inquiry
Description LNP@EGFp-mRNA is a nucleic acid delivery system that encapsulates messenger ribonucleic acid (EGFp-mRNA) encoding enhanced green fluorescent protein inside lipid nanoparticles (LNP). Lipid nanoparticles are mainly composed of ionizable cationic phospholipids, cholesterol, auxiliary phospholipids and polyethylene glycol modified phospholipids. Under physiological pH conditions, ionizable cationic phospholipids are neutral, protonated and positively charged in acidic environments such as endosomes, and can tightly combine with negatively charged EGFp-mRNA through electrostatic interaction to achieve encapsulation. Cholesterol enhances membrane fusion, which helps LNP@EGFp-mRNA to be taken up by cells and promote EGFp-mRNA to escape from endosomes and enter the cytoplasm. Auxiliary phospholipids stabilize the phospholipid bilayer structure and maintain the stability of LNP morphology. Polyethylene glycol-modified phospholipids are located on the surface of LNP to prevent particle aggregation, prolong their circulation time in the body, and avoid rapid clearance by the immune system. After EGFp-mRNA enters the cell, it uses the intracellular translation mechanism to synthesize enhanced green fluorescent protein, which emits green fluorescence when excited by light of a specific wavelength. After combining with LNP, it not only improves the stability and cellular uptake efficiency of EGFp-mRNA, but also visually tracks the delivery and expression process of mRNA through fluorescent signals.
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