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Product Infomation
Product Name LNP@DIO-PTX, DIO and paclitaxel encapsulated in liposomes
Catalog Number R-C-11-DZ
Alias Lipid nanoparticles encapsulating 1,1'-dioctyl-3,3,3',3'-tetramethylindocyanine perchlorate-paclitaxel
Appearance Dispersion
Molecular Formula N/A
Solubility Dispersed in water or PBS buffer
Storage 2-8°C, protected from light
Purity 95%+
Shelf Life 1 year
Shipping Condition low temperature transport
Application Preparation of liposomes
Specification 10mg：Inquiry
20mg：Inquiry
50mg：Inquiry
Description LNP@DIO-PTX is a constructed nanocomplex that encapsulates 1,1′-dioctyl-3,3,3′,3′-tetramethylindocyanine perchlorate-labeled paclitaxel inside lipid nanoparticles. Lipid nanoparticles are mainly composed of ionizable cationic phospholipids, cholesterol, auxiliary phospholipids and polyethylene glycol modified phospholipids. Under physiological pH conditions, ionizable cationic phospholipids are neutral, protonated and positively charged in acidic environments such as endosomes, and can be closely combined with negatively charged or polar DIO-PTX through electrostatic interactions, hydrophobic interactions, etc. to achieve efficient encapsulation. Cholesterol enhances membrane fusion, which helps LNP@DIO-PTX to be taken up by cells and promote DIO-PTX to escape from endosomes and enter the cytoplasm. Auxiliary phospholipids stabilize the phospholipid bilayer structure and maintain the stability of LNP morphology. Polyethylene glycol-modified phospholipids are located on the surface of LNP to prevent particle aggregation, prolong circulation time in the body, and avoid rapid clearance by the immune system.
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