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Product Infomation
Product Name LNP@CY5.5-Alendronate, lipid nanoparticles encapsulating cyanine 5.5-alendronate
Catalog Number R-CW-DZKP002
Alias Lipid nanoparticles encapsulating cyanine 5.5-alendronate
Appearance Dispersion
Molecular Formula N/A
Solubility Dispersed in water or PBS buffer
Storage 2-8°C, protected from light
Purity 95%+
Shelf Life 1 year
Shipping Condition low temperature transport
Application Preparation of liposomes
Specification 10mg：Inquiry
20mg：Inquiry
50mg：Inquiry
Description LNP@CY5.5-Alendronate is a constructed nanocomplex that encapsulates cyanine 5.5-labeled alendronate inside lipid nanoparticles. Lipid nanoparticles are mainly composed of ionizable cationic phospholipids, cholesterol, auxiliary phospholipids and polyethylene glycol modified phospholipids. Under physiological pH conditions, ionizable cationic phospholipids are neutral, protonated and positively charged in acidic environments such as endosomes, and can be closely combined with negatively charged or polar CY5.5-Alendronate through electrostatic interactions, hydrophobic interactions, etc. to achieve efficient encapsulation. Cholesterol enhances membrane fusion and helps LNP@CY5.5-Alendronate to be taken up by cells and promote CY5.5-Alendronate to escape from endosomes and enter the cytoplasm. Auxiliary phospholipids stabilize the phospholipid bilayer structure and maintain the stability of LNP morphology. Polyethylene glycol-modified phospholipids are located on the surface of LNP to prevent particle aggregation, prolong circulation time in the body, and avoid rapid clearance by the immune system. Alendronate is a bisphosphonate compound that can specifically bind to hydroxyapatite in bones and is often used to prevent and treat bone-related diseases such as osteoporosis. Cyanine 5.5 is a commonly used near-infrared fluorescent dye with high photostability and specific emission wavelength. By combining it with alendronate, the fluorescent properties can be used for tracking. After combining with LNP, it not only improves the stability of CY5.5-Alendronate and improves its delivery efficiency in the body, but also enables it to reach bone-related action sites more accurately and perform bone-targeting treatment and tracing functions.
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