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Product Infomation
Product Name LNP@Ce6, lipid nanoparticles encapsulating chlorin e6
Catalog Number R-LNP-C06
Alias Chlorin e6 encapsulated in lipid nanoparticles
Appearance Dispersion
Molecular Formula N/A
Solubility Dispersed in water or PBS buffer
Storage 2-8°C, protected from light
Purity 95%+
Shelf Life 1 year
Shipping Condition low temperature transport
Application Preparation of liposomes
Specification 10mg：Inquiry
20mg：Inquiry
50mg：Inquiry
Description LNP@Ce6 is a constructed nanoscale delivery system that encapsulates hematoporphyrin monomethyl ether inside lipid nanoparticles. Lipid nanoparticles are mainly composed of ionizable cationic phospholipids, cholesterol, auxiliary phospholipids and polyethylene glycol modified phospholipids. Under physiological pH conditions, ionizable cationic phospholipids are neutral, protonated and positively charged in acidic environments such as endosomes, and can tightly combine with negatively charged or polar Ce6 through electrostatic interaction, hydrophobic interaction, etc. to achieve efficient encapsulation. Cholesterol enhances membrane fusion and helps LNP@Ce6 to be taken up by cells and promote Ce6 to escape from endosomes and enter the cytoplasm. Auxiliary phospholipids stabilize the phospholipid bilayer structure and maintain the stability of LNP morphology. Polyethylene glycol-modified phospholipids are located on the surface of LNP to prevent particle aggregation, prolong circulation time in the body, and avoid rapid clearance by the immune system. Hematoporphyrin monomethyl ether is a photosensitizer with photodynamic properties. Under the irradiation of light of a specific wavelength, it can transition from the ground state to the excited state, and then undergo energy transfer with surrounding oxygen molecules to produce reactive oxygen species such as singlet oxygen that are harmful to cells. After combining with LNP, it not only improves the stability of Ce6 and improves its delivery efficiency in the body, but also enables it to reach the site of action more accurately and perform functions such as photodynamic treatment.
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