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Product Infomation
Product Name LNP@BSA-FITC, lipid nanoparticles encapsulating fluorescein isothiocyanate-labeled bovine serum albumin
Catalog Number R-CW-510
Alias Liposome-encapsulated BSA-FITC
Appearance Dispersion
Molecular Formula N/A
Solubility Dispersed in water or PBS buffer
Storage 2-8°C, protected from light
Purity 95%+
Shelf Life 1 year
Shipping Condition low temperature transport
Application Preparation of liposomes
Specification 5ml: Inquiry
10ml: Inquiry
20ml: Inquiry
Description LNP@BSA-FITC is a constructed nanocomplex that encapsulates fluorescein isothiocyanate-labeled bovine serum albumin inside lipid nanoparticles. Lipid nanoparticles are mainly composed of ionizable cationic phospholipids, cholesterol, auxiliary phospholipids and polyethylene glycol modified phospholipids. Under physiological pH conditions, ionizable cationic phospholipids are neutral, protonated and positively charged in acidic environments such as endosomes, and can be tightly combined with negatively charged BSA-FITC through electrostatic interaction to achieve efficient encapsulation. Cholesterol enhances membrane fusion, which helps LNP@BSA-FITC to be taken up by cells and promote BSA-FITC to escape from endosomes and enter the cytoplasm. Auxiliary phospholipids stabilize the phospholipid bilayer structure and maintain the stability of LNP morphology. Polyethylene glycol-modified phospholipids are located on the surface of LNP to prevent particle aggregation, prolong circulation time in the body, and avoid rapid clearance by the immune system. Bovine serum albumin is a carrier protein with good biocompatibility. Its structure contains multiple modifiable sites, and it can achieve fluorescent labeling by reacting with fluorescein isothiocyanate (FITC). FITC has high absorption rate and excellent fluorescence quantum yield. Its isothiocyanate group reacts with the amino terminal or primary amine of BSA, causing BSA to be labeled with green fluorescence. After combining with LNP, it not only improves the stability of BSA-FITC, but also improves its delivery efficiency, allowing it to reach the site of action more accurately and perform functions such as fluorescent tracer and protein carrier.
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