Duodenum Intestine Chip

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Product Infomation

Product Name	Duodenum Intestine Chip
Catalog Number	OOC-030
Description	The duodenal organ-on-a-chip combines primary human duodenal organoids and small intestinal microvascular endothelial cells with mechanical forces that mimic intestinal peristalsis. In this dynamic microenvironment, cells can polarize effectively and exhibit morphology, function, and gene expression similar to those in vivo, while allowing access to the apical cell surface.
Applications	Used to study drug absorption and drug interactions.
Features	Gene expression in this chip more closely resembles that of in vivo tissues than in isolated organoids, with a significant enrichment of pathways related to metabolism, digestion, nutrient transport, and detoxification; it forms a functional intestinal barrier with well-defined epithelial tight junctions and in vivo-like permeability, in contrast to the blurred tight junctions observed in standard cell cultures.

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