DT-061 (SMAP)lipid nanoparticle

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Product Infomation

Product Name	DT-061 (SMAP)lipid nanoparticle
Catalog Number	LNP-009
Size	10 mg; 20 mg; 50 mg
Alias	Small molecule-loaded lipid nanoparticles; Tumor inhibitory phosphatase targeting nanocarriers
Appearance	Milky white to light yellow homogeneous suspension
Solubility	It can be dispersed in physiological buffer (such as PBS)or 5% glucose solution to form a stable colloidal dispersion system
Description	Small molecule-loaded lipid nanoparticles is a specialized nano-lipid nanoparticle formulation of the protein phosphatase 2A small molecule activator DT-061 (SMAP). As a type of allosteric activator that selectively binds and stabilizes the PP2A-B56α isoform, DT-061 can restore the tumor inhibitory activity of PP2A, thereby regulating multiple carcinogenic signaling pathways (such as MAPK, PI3K/akt, wnt, etc.)Through dephosphorylation, inducing tumor cell cycle arrest and apoptosis. However, its limited water solubility, rapid metabolism in the body, and lack of tissue targeting limit its full effect.
Applications	Study on the anti-tumor pharmacodynamics and mechanism of PP2A activators
Storage	4°C, protected from light
Purity	95%+
Shelf Life	1 Year
Shipping Condition	Low temperature transport

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