DOTAP-DOPE Cationic LNP, N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium chloride-dioleoylphosphatidylethanolamine cationic liposomes

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Product Infomation

Product Name	DOTAP-DOPE Cationic LNP, N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium chloride-dioleoylphosphatidylethanolamine cationic liposomes
Catalog Number	R-ZZTBSSDL-134
Alias	Standard vector for gene/nucleic acid delivery
Appearance	Milky white to translucent homogeneous suspension
Molecular Formula	N/A
Solubility	Can be reconstituted in nuclease-free water or HEPES buffer to form a stable colloidal dispersion.
Storage	4°C, protected from light
Purity	95%+
Shelf Life	1 year
Shipping Condition	low temperature transport
Application	In vitro gene transfection and protein expression studies of conventional cell lines
Specification	10mg：Inquiry 20mg：Inquiry 50mg：Inquiry
Description	DOTAP-DOPE Cationic LNP is a representative cationic liposome system used in the field of non-virus gene delivery. It is an optimized compound of the cationic lipid DOTAP (providing permanent positive charge) and the neutral auxiliary phospholipid DOPE (usually at a 1:1 molar ratio). DOTAP combines and compresses negatively charged nucleic acids (DNA, siRNA, mRNA, etc.) through the strong positive charge generated by its quaternary ammonium salt head group to form a stable nanocomplex; while DOPE relies on its unique conical molecular structure to promote the fusion or destruction of liposomes and endosomal membranes after endocytosis, enhance endosomal escape efficiency, and effectively release nucleic acids into the cytoplasm.

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