Distearoylphosphatidylethanolamine-hydrazone bond-polyethylene glycol lipid nanoparticles encapsulating dexamethasone

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Product Infomation

Product Name	Distearoylphosphatidylethanolamine-hydrazone bond-polyethylene glycol lipid nanoparticles encapsulating dexamethasone
Catalog Number	LNP-128
Size	10 mg; 20 mg; 50 mg
Alias	DSPE-HYD-PEGLNP@DEX; Responsive phospholipid-encapsulated drugs
Appearance	Dispersion
Solubility	Stable dispersion in aqueous media such as water and physiological saline
Description	DSPE-HYD-PEGLNP@DEX is a lipid nanoparticle drug delivery system that integrates targeting, responsiveness and drug sustained release functions. It uses distearoylphosphatidylethanolamine (DSPE)and polyethylene glycol (PEG)as the main lipid materials, connected through hydrazone bonds (-C=N-NH-)to form amphipathic lipid molecules, which can self-assemble to form lipid nanoparticles and encapsulate dexamethasone in them. DSPE has good film-forming properties and biofilm compatibility, and can form the hydrophobic core of lipid nanoparticles; PEG gives the nanoparticles good water solubility and steric hindrance effect, reducing recognition and clearance by the immunity system, and prolonging the time in the body circulation; The hydrazone bond is sensitive to acidic environments, and will be rapidly hydrolyzed and broken in acidic microenvironments (pH 5.0-6.5)Such as tumor tissue, prompting the release of dexamethasone.
Applications	Drug delivery system
Storage	2-8°C, protected from light
Purity	95%+
Shelf Life	1 Year
Shipping Condition	Low temperature transport

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