Clophosome-Clodronate LNP,Clophosome®-clodronate liposomes

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Product Infomation

Product Name	Clophosome-Clodronate LNP,Clophosome®-clodronate liposomes
Catalog Number	R-ZZTBSSDL-116
Alias	Clodronate disodium liposome
Appearance	Milky white homogeneous suspension
Molecular Formula	N/A
Solubility	Can be reconstituted in physiological buffer or sterile PBS to form a stable colloidal dispersion system
Storage	4°C, protected from light
Purity	95%+
Shelf Life	1 year
Shipping Condition	low temperature transport
Application	Specific exploration of the role of macrophages in the immune cell interaction network
Specification	10mg：Inquiry 20mg：Inquiry 50mg：Inquiry
Description	Clophosome-Clodronate LNP is a research tool for functionally specific depletion of macrophages, using clodronate (dichloromethylene diphosphonic acid) as the active ingredient and encapsulating it in traditional non-PEGylated liposomes. Clodronate itself is a hydrophilic bisphosphonate that has difficulty penetrating cell membranes in its free state; however, after being encapsulated in liposomes, it can be specifically taken up through macrophage endocytosis, and clodronate is subsequently released into the cell under the action of lysosomes. High concentrations of clodronate accumulate intracellularly, interfere with cellular metabolism and induce macrophage-selective apoptosis, thereby achieving temporary depletion of macrophages locally or systemically.

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