Clodronate-loaded lipid nanoparticles

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Product Infomation

Product Name	Clodronate-loaded lipid nanoparticles
Catalog Number	LPs-001
Size	10 mg; 20 mg; 50 mg
Alias	Clodronate-loaded LNP; Clodronate encapsulated lipid vesicles
Appearance	Milky white homogeneous suspension
Solubility	It can be dispersed in physiological buffer or sterile PBS to form a stable colloidal dispersion system
Description	Clodronate-loaded LNP is a research tool for functionally specific depletion of macrophages, using clodronate (dichloromethylene diphosphonic acid)as the active ingredient and encapsulating it in traditional non-PEGylated lipid nanoparticles. Clodronate itself is a hydrophilic bisphosphonate that has difficulty penetrating cell membranes in its free state; However, after being encapsulated in lipid nanoparticles, it can be specifically taken up through macrophage endocytosis, and clodronate is subsequently released into the cell under the action of lysosomes. High concentrations of clodronate accumulate intracellularly, interfere with cellular metabolism and induce macrophage-selective apoptosis, thereby achieving temporary depletion of macrophages locally or systemically.
Applications	Specific exploration of the role of macrophages in the immune cell interaction network
Storage	4°C, protected from light
Purity	95%+
Shelf Life	1 Year
Shipping Condition	Low temperature transport

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