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Product Infomation
Product Name Cholesterol-es-Lys, cholesterol-succinate-lysine conjugate
Catalog Number R-Cho-es-Lys
Alias Chol-es-Lys
Appearance White to light yellow solid powder or amorphous solid
Molecular Formula C44H72F6N2O9
Solubility Chloroform, methylene chloride, dimethyl sulfoxide (DMSO)
Storage -20°C, protected from light
Purity 95%+
Shelf Life 1 year
Shipping Condition low temperature transport
Application Cationic liposome components
Specification 100mg：Inquiry
200mg：Inquiry
500mg：Inquiry
Description Cho-es-Lys (cholesterol-succinate-lysine conjugate) is a designer amphipathic molecule that combines the membrane-anchoring ability of cholesterol with the charge and reactivity of amino acids. The molecule covalently connects the hydrophobic cholesterol steroid ring structure to the hydrophilic lysine residue through a succinate linking arm to create a structurally multifunctional lipid derivative. The cholesterol moiety serves as a membrane-anchoring module that is able to firmly insert into the hydrophobic core of lipid bilayer membranes, liposomes, or nanoparticles through hydrophobic interactions, giving the entire molecule a stable positioning in the biological membrane environment. Not only does the succinic acid linker provide suitable chain length and flexibility, its carboxylic acid group (usually present as an amide bond after being attached to lysine) also increases the polarity of the molecule. The terminal lysine residue is the functional core of the molecule: its side chain carries a net positive charge (ε-amino protonation) under physiological pH conditions, which makes the entire Cho-es-Lys molecule exhibit cationic properties.
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