CD3/CD28 T Cell Activation Beads, Mouse

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Product Infomation

Product Name	CD3/CD28 T Cell Activation Beads, Mouse
Catalog Number	MGB-CS-022
Size	200 μL for 2×10⁷ cells, 1 mL for 1×10⁸ cells
Physical Specs	5 µm
Description	CD3 and CD28 can be regarded as two important targets for T cell activation. When CD3 and CD28 antibodies are used together to stimulate T cells in vitro, it can simulate the dual signaling effect of T cell activation in vivo. Using this magnetic bead, it is possible to simply and conveniently activate and expand mouse T cells in vitro without adding feeder cells (antigen-presenting cells) or antigens. This product is a 5 µm diameter inert superparamagnetic bead, covalently coupled with anti-mouse CD3 and CD28 antibodies, simulating the activation and expansion of T cells by antigen-presenting cells. After T cell activation and expansion, the activated T cell magnetic beads can be easily removed by magnetic force frame.
Applications	Basic immunology research; cellular immunotherapy: CAR-T cell preparation, animal tumor model studies, etc.; drug and antibody screening: immunomodulatory drugs, antibody functional validation.
Features	Activated T cells can be cultured in vitro for up to 21 days, with a proliferation factor exceeding 1,000-fold; the procedure is simple—cells can be added immediately after washing the magnetic beads, and there is no need to remove them during activation or expansion.

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