Adavosertib LNP,adavosertib liposome

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Product Infomation

Product Name	Adavosertib LNP,adavosertib liposome
Catalog Number	R-ZZTBSSDL-112
Alias	WEE1 kinase inhibitor nanoformulation
Appearance	Milky white to light yellow homogeneous suspension
Molecular Formula	N/A
Solubility	Can be reconstituted in physiological buffer (such as PBS) or 5% glucose solution to form a stable colloidal dispersion system
Storage	4°C, protected from light
Purity	95%+
Shelf Life	1 year
Shipping Condition	low temperature transport
Application	Development of nanodelivery systems targeting DNA damage response pathways
Specification	10mg：Inquiry 20mg：Inquiry 50mg：Inquiry
Description	Adavosertib LNP is a specialized nanoliposome formulation of the WEE1 kinase inhibitor adavosertib (MK-1775). Adavosertib eliminates the cell cycle G2/M checkpoint by selectively inhibiting WEE1 kinase, causing DNA-damaged tumor cells to enter mitosis prematurely, thereby inducing mitotic catastrophe and cell apoptosis. Its combination with DNA damage therapy can produce a strong synergistic effect, but when used alone, its limited water solubility, rapid metabolism in the body, and lack of tumor targeting limit its full effect.

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