Adavosertib lipid nanoparticle

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Product Infomation

Product Name	Adavosertib lipid nanoparticle
Catalog Number	LNP-007
Size	10 mg; 20 mg; 50 mg
Alias	Small molecule drug-loaded lipid nanoparticles; WEE1 kinase inhibitor nanoformulation
Appearance	Milky white to light yellow homogeneous suspension
Solubility	It can be dispersed in physiological buffer (such as PBS)or 5% glucose solution to form a stable colloidal dispersion system
Description	Small molecule drug-loaded lipid nanoparticles is a specialized nano-lipid nanoparticle formulation of the WEE1 kinase inhibitor adavosertib (MK-1775). Adavosertib eliminates the cell cycle G2/M checkpoint by selectively inhibiting WEE1 kinase, causing DNA-damaged tumor cells to enter mitosis prematurely, thereby inducing mitotic catastrophe and cell apoptosis. Its combination with DNA damage research can produce a strong synergistic effect, but when used alone, its limited water solubility, rapid metabolism in the body, and lack of tumor targeting limit its full effect.
Applications	Development of nanodelivery systems targeting DNA damage response pathways
Storage	4°C, protected from light
Purity	95%+
Shelf Life	1 Year
Shipping Condition	Low temperature transport

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