Hyaluronic Acid

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Hyaluronic Acid

Hyaluronic acid (HA) is a non-sulphated glycosaminoglycan (GAG) and is composed of repeating polymeric disaccharides of D-glucuronic acid and N-acetyl-D-glucosamine linked by a glucuronidic β (1→3) bond. It is endowed with unique physiological and biological properties including high water-holding capacity, viscoelasticity and biocompatibility. HA is one of the most hydrophilic (water-loving) molecules in nature and can be described as nature’s moisturizer. It is synthesized by specific enzymes called HA synthases (HAS).

HA occurs in a vast number of configurations and shapes, depending on their size, salt concentration, pH, and associated cations. The commodity usually exists in the form of sodium, so it is also called Sodium Hyaluronate. Ranging from tissue culture scaffolds to cosmetic and food materials, HA has a wide range of unprecedented applications like osteoarthritis treatment, ophthalmic surgery, joint care, skin care, plastic surgery, drug delivery, and wound healing. The content of HA in the human body is about 15 g and conservation function of skin weakens along with HA content decreases and then skin come to rough and wrinkles appears. The oral sodium hyaluronate can support hyaluronic acid levels in the body. Currently, extraction from rooster comb and fermentation of certain attenuated strains of group A and C Streptococcus are commonly exploited for commercial HA production. After years of technological innovation, Matexcel can produce HA with different molecular weights, from 3000 to 2 million Daltons and meet different customer needs such as research, cosmetic, food, injection and eye-drop grades.

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